Science

From swab to sequence

A diagnostic laboratory explains the chain of custody that keeps a sample honest from collection to result.

Every sample that enters the lab arrives in a sealed, labelled bag with a barcode that will follow it for the rest of its life. Scan, log, refrigerate: the routine is deliberately dull, because dullness is what prevents mistakes.

The chain matters most when the result matters most. A mislabelled sample in a public-health investigation can send a whole team in the wrong direction, so every hand-off is double-checked and every freezer is alarmed.

Automation has taken over the pipetting, but the human steps at the start and end of the chain remain. As the lab director put it, the machines are excellent at doing the same thing a thousand times, and terrible at noticing when the thing is wrong.

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